Efficacy and safety of Viagra (Sildenafil) in patients with confirmed ED various etiologies. By 2003, more than 20 million people worldwide have taken Viagra with excellent results. Although ED was caused such severe and difficult to treat diseases, as a radical prostatectomy in patients with prostate cancer, severe diabetes, spinal cord injuries, Viagra and demonstrated its efficacy in these patients. The incidence of adverse cardiovascular effects in patients taking Sildenafil, did not differ from those in the population. The study of the pharmacologic effects of Viagra on ischemic myocardium also confirms the safety of the drug. Viagra has proved safe and effective in patients taking a variety of medications, including some antihypertensive drugs at the same time, selective serotonin reuptake inhibitors, cardiovascular and anti-diabetic medicines.
Short-term Viagra therapy is safe and effective in patients with pulmonary arterial hypertension. However, data on the effect of Viagra (Sildenafil) on survival in patients with idiopathic pulmonary arterial hypertension is rare. In a study at Peking University, studied the effect of treatment with Viagra in 77 patients with newly diagnosed idiopathic pulmonary hypertension in the period from 2005 to 2009. Patients were divided into 2 groups: Sildenafil and traditional therapy. Baseline characteristics of patients receiving Viagra, were similar to the comparison group. Patients in the group receiving Viagra was conducted right heart catheterization at baseline and after 3 months. After 3 months of therapy with Viagra(Sildenafil) showed a significant improvement in the test of 6-minute walk test, myocardial oxygen consumption increased significantly (p <0.05). One-, two-, and three-year-survival rate of patients receiving Viagra was 88, 72 and 68%, respectively, compared with 61, 36 and 27% (p <0.001) of control group. Low body mass index and decreased myocardial oxygen saturation without the use of Viagra were independent predictors of deaths. The use of Sildenafil as pathogenetic therapy is associated with improved survival in patients with idiopathic pulmonary arterial hypertension
Viagra is perfectly combined with cardiovascular drugs. Thiazide diuretics, loop and potassium-sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-blockers, warfarin, aspirin did not affect the pharmacokinetics of Sildenafil. Tolerability is good. The main side effects of Viagra emit transient, they arise in the application of dosages of 100 mg and are characterized by mild or moderate severity (headache, redness of the face and neck, nasal congestion, indigestion). Very rare side effects of Viagra become a cause of discontinuation of treatment. The only contraindication to the use of Viagra is treatment with nitrates because of the risk of hypotension.
Several experimental studies of Viagra are devoted to various aspects of its impact on the organs and tissues. Sildenafil, in particular, may contribute to the restoration of the bone defect. In a study conducted by scientists studied the effect of Viagra on the process of bone healing. 42 male rats Viagra half received 10 mg / kg body weight per day for 30 days and was half of the control group. Rats applied a small surgical defect of leg bones, and in the future the therapy conducted histological, densitometric and MRI study of bone tissue. On the recovery and healing stages were obtained statistically significant differences between the groups, indicating that Viagra accelerates the process of bone repair. The authors suggest that studies relating to the use of Viagra in the treatment of bone regeneration, seems promising.